- by Bangalore Baptist Hospital
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- Nov 14 2017
What is Zollinger –Ellison Syndrome?-By DR. DOMINIC .G. BENJAMIN
It is a disease of the gastrointestinal system and people who have ZES develop tumors known as gastrinomas in the pancreas and duodenum. Gastrinomas secrete the hormone gastrin that creates excessive stomach acid, 90 percent of patients with ZES develop stomach and duodenal ulcers.
Approximately 25% to 30% of ZES patients also have a genetic disorder known as “multiple endocrine neoplasia type 1”, which cause tumors in the pituitary and parathyroid glands. More than half of single gastrinomas are malignant. People with ZES are usually diagnosed between ages 20 and 50.
It is caused by tumors. These growths are most often found in the head of the pancreas and the upper small intestine. The tumors are called gastrinomas and they can occur as a singal tumor or several tumors.
- Abdominal pain
- Burning pain in the abdomen
- Weight loss
- Bleeding from the stomach
- Acid reflux and heartburn
- Decreased appetite
- A blood test is done to look for high levels of gastrin.
- Tests to measure how much acid your stomach is producing.
- Endoscopy to examine gastrinoma.
- CT scan
- PET scan to locate tumors
- Octreotide scan to look for neuroendocrine tumor cells.
- Calcium infusion test
- Secretin stimulation test
- Exploratory surgery
Drugs called proton pump inhibitors are used for treating ZES. The drug reduces the acid production by the stomach. Surgery is done to remove a single gastrinoma if the tumors have not spread to other organs.
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